Spravato® (esketamine) is an FDA-approved nasal spray for adults with:
Spravato is administered in a certified clinic under the FDA’s REMS program and is used together with an oral antidepressant. Unlike traditional SSRIs/SNRIs that may take weeks to work, esketamine targets NMDA receptors to enhance neuroplasticity—the brain’s ability to form new connections—often leading to faster symptom relief (sometimes within hours to days).
REMS requirement: Spravato cannot be dispensed for home use and must be given under direct clinical supervision with post-dose monitoring.
Spravato does not simply increase serotonin or norepinephrine. By modulating the glutamate system at NMDA receptors, it can rapidly strengthen synaptic connectivity linked to mood and cognition, which may help relieve depressive symptoms more quickly.
What to Expect at Each Visit
Your exact plan is personalized, but most patients follow:
We reassess regularly to confirm benefit, adjust the schedule, and review risks/benefits before continuing.
Many commercial and public insurance plans cover Spravato for eligible patients. We handle benefits checks, prior authorizations, and appeals so you can focus on healing. If needed, we’ll discuss manufacturer programs, financing options, or payment plans.
How quickly will I feel better?
Some people notice improvement within hours to days; others may need several sessions. We monitor progress closely and adjust the plan as needed.
Is it safe?
Yes—when delivered in a REMS-certified clinic with proper monitoring. We screen for medical risks and watch your vitals throughout each visit.
Will my insurance cover it?
Often, yes. Coverage varies by plan and indication. Our team will verify benefits and explain your out-of-pocket costs up front.
Can I drive after treatment?
No. Arrange a ride home and avoid driving or operating machinery until the next day
If depression has not responded to standard treatments, Spravato may be an option. Contact Vivabest Psychiatry PLLC to schedule an evaluation and learn whether esketamine treatment is right for you. We’ll guide you through eligibility, coverage, and a personalized care plan designed for real-world relief.
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